Modelling of GPCRs A Practical Handbook /

• Main Authors: Strasser, Andrea. (Author), Wittmann, Hans-Joachim. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic
• Language: English
• Published: Dordrecht : Springer Netherlands : Imprint: Springer, 2013.
• Subjects: Medicine.; Biochemistry.; Computer simulation.; Bioinformatics.; Biology > Data processing.; Biomedicine.; Biomedicine general.; Computational Biology/Bioinformatics.; Computer Appl. in Life Sciences.; Simulation and Modeling.; Medicinal Chemistry.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-94-007-4596-4

G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is ...

Table of Contents:

• Preface
• 1.�Introduction
• 2.�G Protein Coupled Receptors
• 3.�Sequence alignment and homology modelling
• 4.�Construction of ligands
• 5.�Lipids
• 6.�Minimization and molecular dynamics.-�7.�Calculation of Gibbs energy of salvation
• 8.�Special topics in GPCR research
• 9.�Force fields
• 10.�Thermodynamics of ligand-receptor interaction
• 11.�Important LINUX commands
• Literature
• Appendix
• Index.