TGF-ø in Human Disease
Transforming growth factor-ø (TGF-ø) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-ø now is rather...
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| Format: | Electronic |
| Language: | English |
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Tokyo :
Springer Japan : Imprint: Springer,
2013.
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| Online Access: | https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-4-431-54409-8 |
Table of Contents:
- Part I Introduction
- 1 Transforming Growth Factor-ø Signaling
- 2 TGF-ø Signaling in Stem Cell Fate Determination
- 3 Emerging Roles of TGF-ø Co-receptors in Human Disease
- Part II Cancer, Fibrosis, and Inflammation
- 4 TGF-ø in Cancer Stem Cells
- 5 TGF-ø as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition
- 6 TGF-ø as Tumor Suppressor: Lessons from Mouse Models
- 7 The Multifunctional Roles of TGF-ø in Navigating the Metastatic Cascade
- 8 TGF-ø Signaling in Leukemogenesis
- 9 TGF-ø in Skin Cancer and Fibrosis
- 10 The Role of TGF-ø in Cutaneous Melanoma Biology
- 11 The Transforming Growth Factor-Beta (TGF-ø) in Liver Fibrosis
- 12 TGF-ø and Inhibitory Smads in Inflammation
- Part III Cardiovascular Diseases
- 13 TGF-ø and Cardiovascular Disorders
- 14 TGF-ø Signaling in Physiological and Pathological Angiogenesis
- 15 TGF-ø Signaling Pathway and MicroRNAs in Cardiovascular Disease
- Part IV Other Diseases
- 16 TGF-ø and Genetic Skeletal Diseases
- 17 TGF-ø in Brain Disorders
- 18 TGF-ø and Metabolic Homeostasis
- Part V Disease Prognosis and Therapy. 19 Targeting Pro-Angiogenic TGF-ø Signaling in the Tumor Microenvironment.