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Drug Resistance in Leishmania Parasites Consequences, Molecular Mechanisms and Possible Treatments /

One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Ponte-Sucre, Alicia. (Editor), Diaz, Emilia. (Editor), Padrn̤-Nieves, Maritza. (Editor)
Format: Electronic
Language:English
Published: Vienna : Springer Vienna : Imprint: Springer, 2013.
Subjects:
Medicine.
Vaccines.
Drug interactions.
Medical parasitology.
Pharmaceutical technology.
Emerging infectious diseases.
Microbiology.
Medicine & Public Health.
Infectious Diseases.
Drug Resistance.
Pharmaceutical Sciences/Technology.
Vaccine.
Parasitology.
Online Access:https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-7091-1125-3
Table of Contents:
  • Foreword
  • Introduction. Leishmaniasis, the biology of a parasite. Alicia Ponte Sucre
  • I Determinant features in leishmaniasis
  • 1 Molecular evolution and phylogeny of Leishmania. Gabriele Schoenian, Elisa Cupolillo, Isabel Mauricio
  • 2 The role of reservoirs: Canine leishmaniasis. Lenea Campino, Carla Maia
  • 3 Epidemiology of leishmaniasis in the time of drug resistance. Jean Claude Dujardin, Saskya Decuypere
  • II Leishmania and the immune system
  • 4 The role of the immune system in resistance to infection. Lukasz Kedzierski, Krystal J. Evans
  • 5 Vaccination as a control measure. Katrin Fr̃ber , Heidrun Moll
  • 6 Leishmania vaccines: Past, Present and Future. Bhavana Sethu Lakshmi, Rentala Madhubala
  • III Challenges in the diagnosis, treatment and control of leishmaniasis in times of drug resistance
  • 7 Co-infection with HIV. Margriet den Boer, Luis Rivas, Jorge Alvar
  • 8 Visceral leishmaniasis. Shyam Sundar , J aya Chakravarty
  • 9 American Tegumentary leishmaniasis. Olga Zerpa, Alicia Ponte-Sucre
  • IV Molecular features of drug-resistant Leishmania
  • 10 Genetic expression and drug resistance, the role of proteomics. Patricia Cuervo, Jose Batista de Jesus
  • 11 The role of ABC transporters in drug-resistant Leishmania. Adriano C Coelho, Paulo C Cotrim
  • 12 Functional analysis of Leishmania membrane (non ABC) transporters involved in drug resistance. Scott M Landfear
  • 13 Intracellular mechanisms of resistance in Leishmania
  • V Pharmacology and chemotherapy of leishmaniasis. Mitali Chatterjee
  • 14 Classical vs new Treatment regimens. Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos, Vanessa Yardley
  • 15 Drug targets, drug effectors and drug targeting and delivery. Philippe M Loiseau, Gillian Barratt
  • 16 Mechanisms of miltefosine resistance in Leishmania. Francisco Gamarro, Mara̕ P Sǹchez-Caęte, Santiago Castanys
  • 17 P-glycoprotein-like transporters in Leishmania: a search for reversal agents. Bruno Pradines
  • VI Strategies to circumvent drug resistance in Leishmania
  • 18 The relevance of susceptibility tests, breakpoints and markers. Louis Maes, Paul Cos and Simon Croft
  • 19 The Concept of Fitness and drug resistance in Leishmania. Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrn̤-Nieves.

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