Disruption of Protein-Protein Interfaces In Search of New Inhibitors /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Mangani, Stefano. (Editor)
• Format: Electronic
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2013.
• Subjects: Chemistry.; Chemistry, Organic.; Organic Chemistry.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-642-37999-4

"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian r...

Table of Contents:

• Drug discovery by targeting protein-protein interactions
• Protein-Protein Interaction Inhibitors: case studies on small molecules and natural compounds
• Disrupting Protein-Protein Interfaces using GRID Molecular Interaction Fields
• NMR as a tool to target protein-protein interactions
• Protein-protein interactions in the solid state The troubles of crystallizing of protein- protein complexes
• Fluorescence observables and enzyme kinetics in the investigation of PPI modulation by small molecules Detection, mechanistic insight, functional consequences.