Sialo-Xenoantigenic Glycobiology Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation /

• Main Authors: Song, Kwon-Ho. (Author), Kim, Cheorl-Ho. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic
• Language: English
• Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2013.
• Series: Sungkyunkwan University Outstanding Research, 1
• Subjects: Engineering.; Human genetics.; Medicine.; Biochemistry.; Biomedical engineering.; Biomedical Engineering.; Molecular Medicine.; Human Genetics.; Medical Biochemistry.; Biochemistry, general.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-3-642-34094-9

Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acidbased xenoantigenes. In pig to huma...

Table of Contents:

• Screening of pig glycosyltransferase genes related to xenoantigens and their masking
• Cloning and tissue specific expression of pcmah and its alternative transcripts
• Functional characterization of pCMAH in the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-to-human xenotransplantation
• Identification of two alternative promoters of the pig CMP-N-acetylneuraminic acid hydroxylase gene
• Screening for xenoantigenic determinants formed by sialyltransferases.