Peroxisome Proliferator-Activated Receptors Discovery and Recent Advances /

• Main Authors: Youssef, Jihan A. (Author), Badr, Mostafa Z. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic
• Language: English
• Published: Totowa, NJ : Humana Press : Imprint: Humana Press, 2013.
• Subjects: Life sciences.; Biochemistry.; Cell receptors.; Life Sciences.; Biochemistry, general.; Receptors.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-62703-420-3

All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the...

Table of Contents:

• Introduction.-�History of PPAR Discovery:�Peroxisomes
• Peroxisomal biogenesis and diseases
• Peroxisome proliferation.-�Peroxisome Proliferator-Activated Receptors:�Chromosomal location and gene polymorphism
• Protein structure
• PPAR Ligands:�Endogenous ligands
• Exogenous PPAR modulators
• Tissue Distribution and Versatile Functions of PPARs:�Neurological functions of PPARs.-�PPARs and the cardiovascular system.-�PPARs in pulmonary physiology and disease.-�Gastrointestinal roles of PPARs.-�PPAR functions in the liver.-�Roles of PPARs in the pancreas.-�PPARs in the urinary tract physiology and pathophysiology.-�PPARs in the reproductive system
• Bone metabolism and PPARs.-�Roles of PPARs in skeletal muscle biology.-�Skin PPARs.-�PPARs and Drug Metabolism
• Molecular Aspects of PPAR Actions:�Posttranslational control of PPARs.-�Mechanism of action.-�Animal Models in PPAR Research.-�Safety of PPAR Agonists.-�The Future of PPAR Research.