Mitochondrial DNA, Mitochondria, Disease and Stem Cells

• Corporate Author: SpringerLink (Online service)
• Other Authors: St. John, Justin C. (Editor)
• Format: Electronic
• Language: English
• Published: Totowa, NJ : Humana Press : Imprint: Humana Press, 2013.
• Series: Stem Cell Biology and Regenerative Medicine
• Subjects: Life sciences.; Cytology.; Stem cells.; Life Sciences.; Stem Cells.; Cell Biology.; Cell Physiology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-62703-101-1

This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offsprings well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication an...

Table of Contents:

• Clinical Approach to the Diagnosis of Mitochondrial Disease
• Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease
• Embryonic Stem Cells: A Signalling Perspective
• From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) A Mitochondrial Odyssey
• From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases
• The Role of Mitochondrial DNA in Tumor Cells
• Assisted Reproductive Technologies to Prevent the Transmission of mtDNA from one Generation to the Next.