Molecular Genetics of Inflammatory Bowel Disease

• Corporate Author: SpringerLink (Online service)
• Other Authors: D'Amato, Mauro. (Editor), Rioux, John D. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Subjects: Medicine.; Human genetics.; Biomedicine.; Human Genetics.; Molecular Medicine.; Biomedicine general.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-8256-7

Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowle...

Table of Contents:

• Part 1: The Foundation of IBD Genetics, Human and Animal Studies
• A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges
• Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies
• Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease
• Part Two: The Genetic and Molecular Makeup of Inflammatory Bowel Disease
• Complex Disease Genes and their Discovery
• The Genetics of Crohn's Disease
• Genetics of Ulcerative Colitis
• Genetic Overlap between Inflammatory Bowel Disease and Other Diseases
• Molecular Profiling of IBD Subtypes/Response to Therapy
• Epigenetics of Inflammatory Bowel Disease
• Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease
• Nod1 and Nod2 and the Immune Response to Bacteria
• The IL-23-Th17 Axis in Intestinal Inflammation
• Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics
• The Epithelial Barrier
• Host Interactions with Bacteria: From Entente Cordiale to Casus Belli
• Cytokines in Inflammatory Bowel Disease
• Part 4: Concluding Remarks and Future Perspectives
• Towards Personalized Therapy in Inflammatory Bowel Disease
• Index.