Transporters in Drug Development Discovery, Optimization, Clinical Study and Regulation /
Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the inte...
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| Other Authors: | , |
| Format: | Electronic |
| Language: | English |
| Published: |
New York, NY :
Springer New York : Imprint: Springer,
2013.
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| Series: | AAPS Advances in the Pharmaceutical Sciences Series,
7 |
| Subjects: | |
| Online Access: | https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-8229-1 |
Table of Contents:
- Membrane Transporters in ADME
- In Vitro Characterization of Transporter Mediated Permeability
- In Vitro Characterization of Interactions with Drug Transporting Proteins
- In Vivo Characterization of Interactions on Transporters
- Application of Targeted Proteomics in ADME for IVIVE
- Prediction of Transporter Mediated Drug-Drug Interaction from In Vitro Data
- Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM)
- Analysis of Intestinal Transporters
- Analysis of Hepatic Transport Proteins
- Analysis of Renal Transporters
- The Role of Transporters During Drug Development: Regulatory Science Perspective from the FDA
- Industrial Evaluation of Drug Transporters in ADME.