Advances in Chronic Lymphocytic Leukemia

• Corporate Author: SpringerLink (Online service)
• Other Authors: Malek, Sami. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Series: Advances in Experimental Medicine and Biology, 792
• Subjects: Medicine.; Oncology.; Biomedicine.; Cancer Research.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-8051-8

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course.� While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatmen...

Table of Contents:

• Preface
• B-cell receptor and antigens in CLL
• The CLL cell microenvironment
• Acquired genomic copy number aberrations in CLL
• Recurrent gene mutations in CLL
• TP53 aberrations in CLL
• Gene expression and epigenetic deregulation
• Apoptosis deregulation in CLL
• Richters Syndrome
• Molecular biomarkers in chronic lymphocytic leukemia
• Critical Signal Transduction Pathways in CLL
• Immunotherapies in CLL
• Novel therapeutic agents in CLL
• Inherited susceptibility to CLL
• miR deregulations in CLL
• Index.