Protein Tyrosine Phosphatase Control of Metabolism

• Corporate Author: SpringerLink (Online service)
• Other Authors: Bence, Kendra K. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Subjects: Life sciences.; Medicine.; Endocrinology.; Biochemistry.; Life Sciences.; Protein Science.; Biochemistry, general.; Biomedicine general.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-7855-3

Tyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs).� A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play ma...

Table of Contents:

• Redox Regulation of PTPs in Metabolism: Focus on Assays
• Quantitative Modeling of PTPs and Implications for Studying Metabolic Signaling
• Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism
• PTP1B and TCPTP in CNS Signaling and Energy Balance
• PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress
• Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling
• PTP1B in Obesity-Related Cardiovascular Runction
• Role of SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism
• Metabolic Effects of Neural and Pancreatic SHP2
• Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism
• The Role of LMPTP in the Metabolic Syndrome
• Mitogen-Activated Protein Kinase Phosphatases in Metabolism
• Glycogen Metabolism and Lafora Disease
• Index.