Resistance to Immunotherapeutic Antibodies in Cancer Strategies to Overcome Resistance /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Bonavida, Benjamin. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Series: Resistance to Targeted Anti-Cancer Therapeutics, 2
• Subjects: Medicine.; Oncology.; Immunology.; Monoclonal antibodies.; Biomedicine.; Cancer Research.; Molecular Medicine.; Antibodies.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-7654-2

The current application of antibody-meditated targeted therapy against cancer has resulted in significant objective clinical responses, prolongation of survival and even cures. More than 20 mAbs have been approved for human use targeting a range of different cancers. However, a major drawback of mAb...

Table of Contents:

• Preface
• Introduction and generation of chimeric and humanized mAbs
• mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment
• Antibodies directed against different major cancers: Effects when used �alone or in combination with drugs
• Mechanisms of antibodies-mediated responses, in vitro and in vivo
• Molecular Pathways
• Molecular Signatures
• Identification of resistance targets for intervention
• Various chemicals that can sensitize resistant tumor cells
• Other mAbs
• Proteasome inhibitors
• Divalent mAbs
• Antibodies coupled to chemical inhibitors
• Antibodies coupled to cytokines
• Nanoparticles with mAbs
• Index.