Pharmacoresistance in Epilepsy From Genes and Molecules to Promising Therapies /
Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplina...
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| Other Authors: | , |
| Format: | Electronic |
| Language: | English |
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New York, NY :
Springer New York : Imprint: Springer,
2013.
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| Online Access: | https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-6464-8 |
Table of Contents:
- Pharmacoresistance and Epilepsy
- Genes involved in pharmacoresistant epilepsy
- Pathological oscillations in the pharmacoresistant epileptic brain
- Molecular mechanisms of pharmacoresistant epilepsy
- Modifications in the seizures susceptibility by excitotoxic neuronal damage and its possible relationship with the pharmacoresistance
- Intracellular pathways associated with neuronal survival and death in epilepsy
- The role of JNK pathway in the process of excitotoxicity induced by epilepsy and neurodegeneration
- Proteomics-based strategy to identify biomarkers and pharmacological targets in temporal lobe epilepsy
- Abnormalities of GABA system and human pharmacoresistant epilepsy
- Pharmacoresistant epilepsy and immune system
- Contribution of the antiepileptic drug administration regime in the development and/or establishment of pharmacoresistant epilepsy
- Experimental models to study pharmacoresistance in epilepsy
- Resistance to epileptogenesis in the Neotropical rodent Proechimys
- On the development of new antiepileptic drugs for the treatment of pharmacoresistant epilepsy Different approaches to different hypothesis
- Modulating P-glycoprotein regulation as a therapeutic strategy for pharmacoresistant epilepsy
- Vagus Nerve Stimulation for Intractable Seizures
- The role of neuromodulation in the treatment of refractory epilepsy
- Transcranial magnetic stimulation and refractory partial epilepsy
- Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity
- Physical exercise as a strategy to reduce seizure susceptibility.