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130403s2013 xxu| s |||| 0|eng d |
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|a 9781461461999
|9 978-1-4614-6199-9
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|a 10.1007/978-1-4614-6199-9
|2 doi
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|a MED000000
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|a 610
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|a Kauffman, Alexander S.
|e editor.
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|a Kisspeptin Signaling in Reproductive Biology
|c edited by Alexander S. Kauffman, Jeremy T. Smith.
|h [electronic resource] /
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| 264 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2013.
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| 300 |
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|a XII, 514 p. 100 illus., 58 illus. in color.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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| 347 |
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|a text file
|b PDF
|2 rda
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| 490 |
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|a Advances in Experimental Medicine and Biology,
|v 784
|x 0065-2598 ;
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|a Part One: Kisspeptin Signaling in vivo and in vitro -- Kisspeptin: Past, Present and Prologue -- Structure, Synthesis, and Phylogeny of Kisspeptin and its Receptor -- Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects -- The Effects of Kisspeptin on Gonadotropin Release in Non-Human Mammals -- Effects of Kisspeptin on Hormone Secretion in Humans -- Kisspeptin Excitation of GnRH Neurons -- Molecular Biology of the Kisspeptin Receptor: Signaling, Function, and Mutations -- Kisspeptin Antagonists -- Kisspeptin and Clinical Disorders -- Beyond the GnRH Axis: Kisspeptin Regulation of the Oxytocin System in Pregnancy and Lactation -- Part Two: Development and Regulation of Kisspeptin Neurons -- The Development of Kisspeptin Circuits in the Mammalian Brain -- Kisspeptin and Puberty in Mammals -- Sex Steroid Regulation of Kisspeptin Circuits -- Kisspeptin and GnRH Pulse Generation -- Interactions between Kisspeptins and Neurokinin B -- Electrophysiology of Kisspeptin Neurons -- Metabolic Regulation of Kisspeptin -- Circadian Regulation of Kisspeptin in Female Reproductive Functioning -- Kisspeptin and Seasonality of Reproduction -- Stress Regulation of Kisspeptin in the Modulation of Reproductive Function -- Effects of Environmental Endocrine Disruptors and Phytoestrogens on the Kisspeptin System -- Model Systems for Studying Kisspeptin Signaling: Mice and Cells -- Index.
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| 520 |
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|a Kisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood.� This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known.� The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function.� Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.
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|a Medicine.
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| 650 |
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|a Neurosciences.
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| 650 |
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|a Endocrinology.
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| 650 |
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|a Reproductive Medicine.
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| 650 |
1 |
4 |
|a Biomedicine.
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| 650 |
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4 |
|a Biomedicine general.
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| 650 |
2 |
4 |
|a Endocrinology.
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| 650 |
2 |
4 |
|a Reproductive Medicine.
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| 650 |
2 |
4 |
|a Neurosciences.
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| 700 |
1 |
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|a Smith, Jeremy T.
|e editor.
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| 710 |
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|a SpringerLink (Online service)
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| 773 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9781461461982
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| 830 |
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|a Advances in Experimental Medicine and Biology,
|v 784
|x 0065-2598 ;
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| 856 |
4 |
0 |
|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-6199-9
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| 912 |
# |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
|