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130217s2013 xxu| s |||| 0|eng d |
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|a 9781461461821
|9 978-1-4614-6182-1
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|a 10.1007/978-1-4614-6182-1
|2 doi
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|a RC261-271
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|a MJCL
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|a MED062000
|2 bisacsh
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|a 614.5999
|2 23
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|a Wang, Zhou.
|e editor.
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|a Androgen-Responsive Genes in Prostate Cancer
|b Regulation, Function and Clinical Applications /
|c edited by Zhou Wang.
|h [electronic resource] :
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2013.
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| 300 |
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|a IX, 348 p. 43 illus., 35 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
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|a text file
|b PDF
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|a Preface -- Roles of androgen receptor coregulators and cell signaling in regulation of androgen-responsive genes -- Selective and classical Androgen Response Elements in androgen-regulated gene expression -- Negative androgen-response elements in androgen target genes -- Chromatin looping and long distance regulation by androgen receptor -- The Functionality of Prostate Cancer Predisposition Risk Regions is revealed by AR Enhancers -- Mechanisms of ARE-independent Gene Activation by the Androgen Receptor in Prostate Cancer Cells: potential targets for better intervention strategies -- Androgen action, Wnt signaling, and prostate tumorigenesis -- Toward Revealing the Complexity of Androgen Responsive Protein and Non-coding Transcripts in Prostate Cancer -- Androgen-Responsive Gene Expression in Prostate Cancer Progression -- Androgen receptor regulated genes in prostate cancer initiation vs metastasis -- Androgen-Independent Induction of Androgen-Responsive Genes By Interleukin-6 Regulation -- The effect of AR overexpression on androgen signaling in prostate cancer -- The expression signature of androgen receptor splice variants and their distinctive transcriptional activities in castration-resistant prostate cancer -- Androgen regulation of the cell cycle in prostate cancer -- Androgen Receptor Signaling Interactions Control Epithelial-Mesenchymal Transition (EMT) in Prostate Cancer Progression -- Androgen receptor regulation of serum response factor signaling in prostate cancer -- Regulation of angiogenesis by androgen-responsive gene EAF2 -- The role of miR-21, an androgen-regulated microRNA, in prostate cancer -- Androgen dependent oncogenic activation of ETS transcription factors by recurrent gene fusions in prostate cancer: Biological and Clinical Implications -- Clusterin as a target for treatment of castration-resistant prostate cancer -- Index.
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|a Recent studies demonstrated a key role of the androgen receptor in the development of castration-recurrent or -resistant prostate cancer (CRPC), which is deadly and in urgent need of more effective therapies.� Understanding the functions of androgen-responsive genes and their regulation and deregulation in prostate cancer progression may lead to new approaches to prevent and treat prostate cancer patients.� This book provides an up-to-date review of the overall androgen-responsive gene expression program and the regulation, function, and clinical relevance of both protein coding and non-coding androgen-responsive genes.� Experts in the field of androgen action and prostate cancer research discussed the importance of DNA elements, chromatin structure, cellular signaling, and cell-cell interactions in the regulation of androgen-responsive genes in the context of prostate cancer progression, including the development of CRPC.� This book is intended for individuals interested in cancer endocrinology and medical and healthcare professionals involved in prostate cancer research.
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|a Medicine.
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|a Oncology.
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|a Human genetics.
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|a Gene therapy.
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|a Biomedicine.
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|a Cancer Research.
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| 650 |
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|a Gene Therapy.
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| 650 |
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|a Human Genetics.
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| 710 |
2 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9781461461814
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| 856 |
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|u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-6182-1
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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