Pathobiology of Cancer Regimen-Related Toxicities

• Corporate Author: SpringerLink (Online service)
• Other Authors: Sonis, Stephen T. (Editor), Keefe, Dorothy M. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Subjects: Medicine.; Oncology.; Toxicology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-5438-0

Toxicities have been consistent undesirable companions of every form of radiation and drug cancer treatment regimens.� In addition to the potential for toxicities to devastate patients quality of life, they generate huge incremental financial costs, and sap patients ability to tolerate definitive...

Table of Contents:

• Preface.-Epidemiology and outcomes of regimen-related toxicities
• The biological basis for differences in normal tissue response to radiation therapy and strategies to establish predictive assays for individual complication risk
• The bystander effect: Ionizing radiation-induced non-targeted effects: Evidence, mechanism and significance
• The role of genes on the metabolism of chemotherapeutic agents and their impact on toxicity.-� Animal models of regimen-related toxicities
• Nausea and Vomiting
• Mucositis
• Dermatitis and Alopecia.-� Fibrosis.-� Myelosuppression
• Neuropathy
• Fatigue
• Xerostomia
• Osteonecrosis
• Conclusions and therapeutic opportunities
• Index.