Ten Years of Progress in GW/P Body Research

• Corporate Author: SpringerLink (Online service)
• Other Authors: Chan, Edward K. L. (Editor), Fritzler, Marvin J. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Series: Advances in Experimental Medicine and Biology, 768
• Subjects: Medicine.; Human genetics.; Biochemistry.; Cytology.; Biomedicine.; Human Genetics.; Cell Biology.; Biochemistry, general.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-5107-5

GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chans group in 2002.�These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation.�The detailed biolo...

Table of Contents:

• Preface
• The GW body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology
• The Discovery of GW Bodies
• The Discovery and Analysis of P Bodies
• Autoantibodies to Argonaute 2 (Su antigen)
• GW/P Bodies and Autoimmune Disease
• Function of GW182 and GW Bodies in siRNA and miRNA Pathways
• Post-Transcriptional Stimulation of Gene Expression by MicroRNAs
• Gawky (Gw) is the Drosophila Melanogaster GW182 Homologue
• The Role of GW182 Proteins in miRNA-mediated Gene Silencing
• Quantifying Argonaute Proteins in and out of GW/P-bodies: Implications in microRNA Activities
• Deadenylation and P-bodies
• Relationship of GW/P-bodies with Stress Granules
• Relationship of other Cytoplasmic Ribonucleoprotein (RNP) Bodies to GW/P Bodies
• A SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182
• Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research
• Index.