DNA Helicases and DNA Motor Proteins

• Corporate Author: SpringerLink (Online service)
• Other Authors: Spies, Maria. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Series: Advances in Experimental Medicine and Biology, 973
• Subjects: Medicine.; Human genetics.; Biochemistry.; Cytology.; Biomedicine.; Human Genetics.; Biochemistry, general.; Cell Biology.; Biomedicine general.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-5037-5

In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to disti...

Table of Contents:

• Preface
• Overview: What are DNA helicases?
• Structure and mechanisms of SF1 DNA helicases
• Structure and mechanisms of SF2 DNA helicases
• Structure and mechanisms of hexameric helicases
• Helicases at the replication fork
• DNA helicases associated with genetic instability, cancer and aging
• The Helicase-primase complex as a target for effective herpesvirus antivirals
• RecQ helicases - conserved guardians of genetic integrity
• Roles of DNA helicases in the mediation and rRegulation of homologous recombination
• DNA helicases in NER, BER and�MMR
• Roles for helicases as ATP-dependent molecular switches
• The FtsK family of DNA pumps
• ATP dependent chromatin remodelers
• Index.