Cancer Immunotherapy Paradigms, Practice and Promise /

This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical tr...

Full description

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Curiel, Tyler J. (Editor)
Format: Electronic
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2013.
Subjects:
Online Access:https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-4732-0
LEADER 03743nam a22004215i 4500
001 13128
003 DE-He213
005 20130727041310.0
007 cr nn 008mamaa
008 121116s2013 xxu| s |||| 0|eng d
020 # # |a 9781461447320  |9 978-1-4614-4732-0 
024 7 # |a 10.1007/978-1-4614-4732-0  |2 doi 
050 # 4 |a RC261-271 
072 # 7 |a MJCL  |2 bicssc 
072 # 7 |a MED062000  |2 bisacsh 
082 0 4 |a 614.5999  |2 23 
100 1 # |a Curiel, Tyler J.  |e editor. 
245 1 0 |a Cancer Immunotherapy  |b Paradigms, Practice and Promise /  |c edited by Tyler J. Curiel.  |h [electronic resource] : 
264 # 1 |a New York, NY :  |b Springer New York :  |b Imprint: Springer,  |c 2013. 
300 # # |a IX, 483 p. 19 illus., 16 illus. in color.  |b online resource. 
336 # # |a text  |b txt  |2 rdacontent 
337 # # |a computer  |b c  |2 rdamedia 
338 # # |a online resource  |b cr  |2 rdacarrier 
347 # # |a text file  |b PDF  |2 rda 
505 0 # |a Introduction -- Historical Perspectives and Current Trends in Cancer Immunotherapy -- T cell and Antigen-Presenting Cell Subsets in the Tumor Microenvironment -- Adoptive T Cell Transfer -- Dendritic Cell-Based Cancer Immunotherapy: Achievements and novel concepts -- Peptide and Protein-based Cancer Vaccines -- Antigen Targeting to Dendritic Cells for Cancer Immunotherapy -- Cytokines in the Treatment of Cancer -- Immune Co-signaling to Treat Cance -- Managing Regulatory T cells -- Myeloid-Derived Suppressor Cells in Cancer: Mechanisms and therapeutic perspectives -- Antibodies as Cancer Immunotherapy -- Targeted Toxins in Cancer Immunotherapy -- Miscellaneous Approaches and Considerations: TLR agonists and other inflammatory agents, anti-chemokine agents, infectious agents, tumor stroma targeting, age and sex effects, and miscellaneous small molecules -- Issues in Pre-clinical Models, Clinical Trial Design and Analytical Considerations in Developing and Evaluating Novel Cancer Immunotherapies -- Monitoring Antigen-Specific Responses in Clinical Trials of Immunotherapy -- Index. 
520 # # |a This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies. Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy. Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press. 
650 # 0 |a Medicine. 
650 # 0 |a Oncology. 
650 # 0 |a Toxicology. 
650 1 4 |a Biomedicine. 
650 2 4 |a Cancer Research. 
650 2 4 |a Pharmacology/Toxicology. 
710 2 # |a SpringerLink (Online service) 
773 0 # |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9781461447313 
856 4 0 |u https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-4732-0 
912 # # |a ZDB-2-SBL 
950 # # |a Biomedical and Life Sciences (Springer-11642)