Systems Biology of Apoptosis

• Corporate Author: SpringerLink (Online service)
• Other Authors: Lavrik, Inna N. (Editor)
• Format: Electronic
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Subjects: Life sciences.; Medicine.; Biological models.; Cytology.; Life Sciences.; Systems Biology.; Apoptosis.; Biomedicine general.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4614-4009-3

Apoptosis is highly defined programmed cell death, which leads to the elimination of cells. Deregulation of programmed cell death is associated with serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. In recent years, apoptosis has been successfully studied using a systems bio...

Table of Contents:

• Preface
• Modeling formalisms in systems biology of apoptosis
• Systems biology of death receptor-induced apoptosis
• Systematic complexity reduction of signaling models and application to a CD95 signaling model for apoptosis
• Systems Biology of the Mitochondrial Apoptosis Pathway
• Systems biology of cell death in hepatocytes
• Understanding different types of cell death using Systems Biology
• Modeling Single Cells in Systems Biology
• Cytokine-cytokine crosstalk and cell-death decisions
• Genetic and genomic dissection of apoptosis signaling
• Index.