Characterization of Protein Therapeutics using Mass Spectrometry

• Corporate Author: SpringerLink (Online service)
• Other Authors: Chen, Guodong. (Editor)
• Format: Electronic
• Language: English
• Published: Boston, MA : Springer US : Imprint: Springer, 2013.
• Subjects: Chemistry.; Human genetics.; Pharmaceutical technology.; Mass spectrometry.; Biotechnology.; Biochemistry.; Surfaces (Physics).; Mass Spectrometry.; Protein Science.; Pharmaceutical Sciences/Technology.; Human Genetics.; Characterization and Evaluation of Materials.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-1-4419-7862-2

Protein therapeutics high efficacy, safety, and ability to treat life-threatening diseases such as cancer, inflammation and genetic disorders have revolutionized modern medicine. In 2012, 200 companies competed in this $90 billion year industry. � In Characterization of Protein Therapeutics using M...

Table of Contents:

• Characterization of Protein Therapeutics by Mass Spectrometry: Recent Developments and Future Directions
• The Use of Mass Spectrometry to Characterize the Metabolism of Peptide Therapeutics
• Quantitative Analysis of Biologics Using Mass Spectrometry
• Maximizing Structural Information from Whole Protein Tandem Mass Spectrometry
• Disulfide Linkages of an Albumin Fusion Protein
• Detailed Structural Characterization of Monoclonal Antibodies
• Application of Protein Mass Spectrometry in Impurity and Degradant Characterization
• Mass Spectrometry Methods to Analyze Higher Order Structure of Protein Therapeutics by Chemical Footprinting
• Aglycosylations Alters Protein Conformation in Antibodies Engineered with Specific Effector Functions Using HDX-MS
• Characterizing Biotherapeutic Protein 3D Structures by Electrospray Ion-Mobility Mass Spectrometry
• Oxford University, Characterization of Assemblies of Proteins by Mass Spectrometry.