Nuclear Receptors Current Concepts and Future Challenges /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Bunce, Chris M. (Editor), Campbell, Moray J. (Editor)
• Format: Electronic
• Language: English
• Published: Dordrecht : Springer Netherlands, 2010.
• Series: Proteins and Cell Regulation ; 8
• Subjects: Medicine.; Endocrinology.; Oncology.; Biochemistry.; Cytology.; Biomedicine.; Biomedicine general.; Cell Biology.; Animal Biochemistry.
• Online Access: https://ezaccess.library.uitm.edu.my/login?url=http://dx.doi.org/10.1007/978-90-481-3303-1

In 1890 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the immediate improvement in the patients condition. A few years later, medications for the then ill-explained condition of the menopause included tablets made from cow ovaries. In the first quarter o...

Table of Contents:

• Preface
• Nuclear Receptors an introductory overview
• What does evolution teach us about Nuclear Receptors?- Functions of Nuclear Receptors in Insect Development
• The Glucocorticoid Receptor
• Estrogen Receptors: Their actions and functional roles in health and disease
• Androgen Receptor
• Thyroid hormone receptors
• The Vitamin D receptor
• Retinoic acid Receptors
• PPARs: important regulators in metabolism and inflammation
• Xenobiotic Receptors CAR and PXR
• FXR
• Physiological Functions of TR2 and TR4 Orphan Nuclear Receptor
• Nuclear Receptors and ATP Dependent Chromatin Remodeling: A Complex Story
• Non-Genomic Action of Sex Steroid Hormones
• Ligand regulation and nuclear receptor action
• New insights to nuclear receptor gene regulation from analysis of their response elements in target genes
• Systems biology: towards realistic and useful models of molecular networks
• Index.